VASCULAR BIOLOGY Platelets can enhance vascular permeability
نویسندگان
چکیده
1Centre de Recherche en Rhumatologie et Immunologie, Centre de Recherche du Centre Hospitalier Universitaire de Québec, Faculté de Médecine de l’Université Laval, Québec, QC; 2Centre de Recherche du Centre Hospitalier Universitaire de Québec and Department of Molecular Medicine, Université Laval, Québec, QC; 3Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom; 4University of Pennsylvania and Veterans Administration Medical Center, Philadelphia, PA; and 5Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA
منابع مشابه
Platelets can enhance vascular permeability.
Platelets survey blood vessels, searching for endothelial damage and preventing loss of vascular integrity. However, there are circumstances where vascular permeability increases, suggesting that platelets sometimes fail to fulfill their expected function. Human inflammatory arthritis is associated with tissue edema attributed to enhanced permeability of the synovial microvasculature. Murine st...
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OBJECTIVE Coated-platelets are a subset of cells observed during costimulation of platelets with collagen and thrombin. Important characteristics of coated-platelets include retention of multiple alpha-granule proteins and expression of phosphatidylserine on the cell surface. The mitochondrial permeability transition pore (MPTP) is a key step in apoptosis and is suggested to be involved in some...
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The role of platelets in responding to vascular injury and the prevention blood loss is very well understood. Cloutier and colleagues have now used fluorescent microspheres, 2-photon microscopy, and genetically modified mice to convincingly demonstrate that in addition to their role in hemostasis, platelets can also promote vascular leakage. More importantly, using a model of rheumatoid arthrit...
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Platelets are a rich source of different chemokines and express chemokine receptors. CXCL4 is highly abundant in platelets and involved in promoting monocyte arrest from rolling and monocyte differentiation to macrophages. CXCL4 can also associate with CCL5 and amplify its effect on monocytes. The megakaryocyte CXCL7 gene product is proteolytically cleaved into the strong neutrophil chemoattrac...
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تاریخ انتشار 2012